Celebrating the Small Steps That Move Science Forward

In science, it is important to celebrate not only the major discoveries, but also the many smaller milestones that make those discoveries possible. Behind every impactful paper are years of optimization, troubleshooting, and method development that often go unseen.

In our lab, we strongly believe that sharing methods is essential for improving rigor, reproducibility, and accessibility across the scientific community. This year, we were excited to publish two methods papers that became fundamental tools supporting our 2023 Cell Reports paper on eosinophils and Bordetella study and now serve as a foundation for many of our ongoing projects.

These papers build upon the work of many pioneers in the field, whose contributions allowed us to take these approaches a step further. Importantly, we also incorporated machine learning approaches to develop tools that help standardize the evaluation of lung microscopy and immunological architecture, improving consistency and reducing bias in analysis.

But beyond the techniques and computational tools, these methods represent the dedication of trainees who spent countless hours, sometimes literally nights in the lab, working to refine protocols, improve reproducibility, and better tailor these approaches to studying eosinophil effector functions during bacterial infections and lung immune architectural

organization.

We are incredibly proud of the work behind these studies and excited to continue building on this foundation.

🔬 Read our research paper:Cell Reports study

🧪 Explore the methods papers:Methods paper 1 Methods paper 2